Hepatic venous pressure gradient (HVPG) predicts variceal development, bleeding, clinical decompensation and death. Measurement is invasive, time-consuming and performed in few centres. Reduction of HVPG to ≥12 mm Hg or by >20% significantly reduces bleeding risk and mortality. Detection of non-responders requires repeated HVPG measurement as conventional non-invasive assessment is not accurate in predicting haemodynamic response. Cirrhotics have a hyperdynamic circulation and impaired baroreceptor sensitivity (BRS). The authors assessed whether non-invasive measurement of systemic haemodynamics and BRS detected clinically significant portal hypertension (CSPH, HVPG ≥12 mm Hg).
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机译：肝静脉压力梯度（HVPG）可预测静脉曲张的发展，出血，临床代偿失调和死亡。测量是侵入性的，耗时的，并且在几个中心进行。将HVPG降低至≥12 mm Hg或> 20％，可显着降低出血风险和死亡率。检测无反应者需要重复HVPG测量，因为常规的非侵入性评估不能准确预测血流动力学反应。肝硬化患者血液循环亢进，压力感受器敏感性（BRS）受损。作者评估了系统性血流动力学和BRS的无创测量是否检测到临床上显着的门脉高压症（CSPH，HVPG≥12 mm Hg）。
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